
PicoSure PRO
PicoSure PRO in London is the gold standard picosecond laser for pigmentation, melasma, sun damage, and acne scarring. It is the only FDA approved laser specifically indicated for the treatment of melasma. At Dr Ophelia's Harley Street clinic, PicoSure PRO is delivered within a full 360 degree dermatologist led approach that combines laser treatment with prescription skincare, oral therapies, and hormonal assessment where indicated. Pigmentation, particularly in darker skin tones, demands far more than a laser session alone to achieve lasting, safe results.
As a Consultant Dermatologist of Indian heritage, Dr Ophelia understands firsthand the complexity of pigmentation in skin of colour: how it arises, how easily it can be worsened by the wrong treatment, and what it genuinely takes to treat it well. This includes expertise to assess hormonal contributors such as HRT and the contraceptive pill, manage underlying inflammatory skin conditions that drive post inflammatory hyperpigmentation, and deliver laser treatment at clinically appropriate energies under proper medical supervision. PicoSure PRO works by shattering pigment using ultra rapid pulses of energy without relying on heat, making it one of the most powerful and precise tools available for treating even the most challenging pigmentation conditions across all skin types.
What is PicoSure PRO?
- FDA approved for melasma
- No heat - shatters pigment
- Safe across all skin types
- Full 360 degree medical approach
PicoSure PRO is an advanced picosecond laser delivering energy in pulses measured in trillionths of a second, far faster than traditional nanosecond lasers. This ultra rapid delivery creates a photoacoustic, pressure based effect within the skin rather than a thermal one, shattering pigment into fine particles the body clears naturally over time. Heat based lasers carry a real risk of triggering post inflammatory hyperpigmentation, worsening the very problem they are intended to treat. PicoSure PRO's non thermal mechanism makes it significantly safer across a wider range of skin types and is the reason it holds FDA approval specifically for melasma. At Dr Ophelia's clinic, every patient receives a full clinical assessment considering the underlying cause alongside prescription topical agents, bespoke prescription pigmentation serums, oral tranexamic acid, Heliocare Fernblock, and hormonal assessment where relevant.
How Does PicoSure PRO Work?
PicoSure PRO uses picosecond technology to exert a photoacoustic pressure based force on pigment granules, fragmenting them without the thermal injury conventional lasers produce. The body's lymphatic system then gradually clears the shattered particles, resulting in progressive lightening over a course of treatments. For skin rejuvenation and acne scarring, the Focus lens array attachment concentrates laser energy into precise microbeams, stimulating collagen and elastin production and producing progressive improvements in texture, pore size, and scarring.
For pigmentation around the eyes including dark circles with a melanin component, Dr Ophelia's clinic uses intraocular eye shields placed directly over the eye, providing complete globe protection and allowing the laser to be used safely right to the orbital rim. Very few clinics in the UK offer this capability. Energy levels are selected by a Consultant Dermatologist and adjusted at every visit based on VISIA imaging data, not the conservative low energy protocols typical of non medical clinics.

Benefits of PicoSure PRO
- The only FDA approved laser treatment specifically indicated for melasma
- Shatters pigment without heat, reducing the risk of post inflammatory hyperpigmentation
- Strong topical anaesthetic (23% lidocaine with 7% tetracaine) applied for up to one hour; most other clinics offer no numbing at all
- Intraocular eye shields for periorbital treatment, allowing safe laser application to the full eye area; unavailable at most clinics
- Clinically appropriate energy levels selected by a Consultant Dermatologist, producing more effective results per session than low energy protocols at non medical clinics
- Suitable for a wide range of skin types including skin of colour, following careful clinical assessment
- Effective for sunspots, lentigines, post inflammatory hyperpigmentation, melasma, and uneven skin tone
- Stimulates collagen and elastin for improved texture, pore refinement, and acne scarring
- Hormonal contributors to pigmentation including HRT and hormonal contraception assessed and addressed where relevant
- Supported by Dr Ophelia's bespoke prescription pigmentation serums, formulated specifically for use around treatment
- Oral tranexamic acid and Heliocare Fernblock prescribed where appropriate to reduce pigmentation recurrence
- Underlying inflammatory conditions including eczema and acne assessed and managed as part of the plan
- Objective progress monitoring with VISIA skin analysis and medical photography at every visit
- Minimal downtime; most patients return to normal activities the same day
Conditions PicoSure PRO Can Treat
PicoSure PRO can be used as a standalone treatment or as part of a comprehensive dermatologist led pigmentation plan for a range of skin concerns, including:
- Melasma
- Post inflammatory hyperpigmentation
- Hormonally driven pigmentation
- Sun damage and solar lentigines
- Sunspots and age spots
- Dark circles (melanin component)
- Periorbital pigmentation
- Uneven skin tone and dullness
- Acne scarring and skin texture
- Enlarged pores
- Fine lines and early photoageing
- Tattoo removal
- General skin rejuvenation
Your consultation with Dr Ophelia will determine whether PicoSure PRO is the right first line treatment, whether it is best used alongside or sequenced with other modalities such as VI Peel, Clear + Brilliant, IPL, or Fraxel laser, and what a realistic treatment plan looks like for your skin type and concern.
What to Expect – Step by Step Treatment Process
Your PicoSure PRO treatment begins with a full dermatologist led consultation and skin assessment. For pigmentation and skin of colour, this stage is the foundation on which a safe and effective treatment plan is built.
Dr Ophelia assesses skin type, pigmentation pattern, medical history, hormonal history, and any underlying skin conditions. VISIA skin analysis and medical photography provide an objective baseline repeated at every visit.
Minimise sun exposure and pause active skincare ingredients including retinoids and exfoliating acids before your appointment. Patients on Dr Ophelia's prescription pigmentation programme receive specific guidance on the Hyperpigmentation Day Serum, Night Serum, and Eye Night Serum alongside their laser schedule. SPF 50 is essential.
The treatment area is thoroughly cleansed to remove SPF, make up, oil, and surface impurities before anaesthetic is applied.
A high strength topical anaesthetic (23% lidocaine with 7% tetracaine) is applied for up to one hour, significantly stronger than anything available over the counter, making PicoSure PRO highly comfortable for the vast majority of patients.
Certified laser safety goggles are worn for non periorbital treatments. For patients treating dark circles and periorbital pigmentation, intraocular eye shields are placed directly on the eye, allowing safe treatment of the full periorbital zone; unavailable at most clinics.
The laser handpiece is passed over the treatment area using settings selected for your skin type and concern. Treatment time varies depending on the area and indication.
The skin is cooled and calming products applied. Full written aftercare instructions are provided including SPF guidance and advice on Dr Ophelia's prescription serums.
At every visit the treatment plan is reviewed in full, the prescription skincare programme adjusted as needed, and energy parameters recalibrated based on how the skin has responded. This ongoing medical oversight supported by VISIA imaging at every visit is what distinguishes a dermatologist led pigmentation programme from a standalone laser clinic.

Results and Downtime
Immediately Mild redness, warmth, and a sensation similar to mild sunburn are common. Pigmented lesions may appear temporarily darker, which is a normal part of the treatment process.
24 to 48 hours Redness settles. Make up can usually be worn and Dr Ophelia's prescription serums reintroduced as advised.
3 to 7 days The skin may feel slightly dry. Gentle skincare and SPF 50 are essential; retinoids and exfoliating acids should be avoided until advised.
1 to 2 weeks Improved clarity, brightness, and evenness become visible. Darker pigmented lesions may flake or fade.
Course of Treatments Sustained improvement develops over 3 to 6 treatments spaced 4 to 6 weeks apart. Meaningful results are typically achieved in fewer sessions than at non medical laser clinics.
Long Term Results With consistent sun protection and Dr Ophelia's prescription skincare programme, improvements in pigmentation can be long lasting. Melasma can recur with UV exposure or hormonal changes; maintenance treatment alongside Heliocare Fernblock is often recommended. There is no significant downtime and most patients return to normal activities the same day.

Pricing and Number of Sessions
The number of sessions required depends on the concern, skin type, extent of pigmentation or scarring, and treatment area. A typical course involves 3 to 6 sessions spaced 4 to 6 weeks apart. Because treatment is delivered at clinically appropriate energies with objective assessment at every visit, many patients require fewer total sessions than they have needed at other clinics. Tattoo removal or deeper pigmentation may require additional sessions. Dr Ophelia's bespoke Hyperpigmentation Day Serum, Night Serum, and Eye Night Serum are available as part of a full treatment programme; oral tranexamic acid and Heliocare Fernblock are prescribed separately where clinically appropriate. Full pricing is provided at consultation and a clear personalised cost breakdown is given before any treatment proceeds.
REAL STORIES OF HEALING AND HOPE
Our Patients' Journeys
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Why Dr Ophelia for PicoSure PRO in London?
- Only FDA approved laser for melasma; the most evidence backed picosecond device for pigmentation
- 23% lidocaine and 7% tetracaine anaesthetic protocol; up to one hour of numbing for genuine comfort; most clinics offer nothing
- Intraocular eye shields for periorbital treatment; safe laser treatment of the full eye area; unavailable at most clinics
- Consultant Dermatologist led energy protocols; clinically calibrated settings that produce better results in fewer sessions
Dr Ophelia's approach begins with a diagnosis, not a device: understanding why the pigmentation is there, what type it is, whether hormonal or inflammatory factors are driving it, and which combination of treatments is safest and most effective. In many aesthetic clinics, PicoSure PRO is operated by therapists with minimal device training and deliberately conservative parameters, meaning patients often need substantially more sessions to see results. At Dr Ophelia's clinic, parameters are set and adjusted by a Consultant Dermatologist at every visit, producing outcomes meaningfully different from those at a beauty or aesthetic setting.
For patients whose pigmentation is driven by hormonal factors including HRT, the combined oral contraceptive pill, or other hormonal medications, Dr Ophelia can advise directly and facilitate onward referral to colleagues in endocrinology, gynaecology, or menopause medicine where needed. For patients whose pigmentation is driven by an underlying inflammatory skin condition such as acne, eczema, or psoriasis, Dr Ophelia has the dermatological expertise to manage the full clinical picture alongside the laser programme. All patients are monitored with VISIA skin analysis and standardised medical photography throughout, providing objective evidence of progress at every visit.
HELP
Frequently asked questions
Treatment is delivered by a Consultant Dermatologist using clinically appropriate energy protocols, with a high strength topical anaesthetic applied for up to one hour, intraocular eye shields for periorbital treatment, and a full 360 degree medical assessment addressing the underlying cause of pigmentation including hormonal and inflammatory contributors.
Energy level directly affects how much pigment is fragmented per session. Many clinics use conservative low energy settings meaning more sessions are needed to see results. At Dr Ophelia's clinic parameters are adjusted by a Consultant Dermatologist at every visit based on objective VISIA imaging, producing more significant results in fewer sessions.
A pharmaceutical grade 23% lidocaine with 7% tetracaine anaesthetic is applied for up to one hour, significantly stronger than anything over the counter. Most UK laser clinics apply no topical anaesthetic before PicoSure PRO. Proper comfort allows the procedure to be performed thoroughly at appropriate energy levels.
Yes. Intraocular eye shields placed directly on the eye allow the laser to be used safely across the full periorbital zone. This is unavailable at most aesthetic clinics and is essential for treating dark circles and periorbital pigmentation properly.
Yes. HRT and the combined oral contraceptive pill are among the most common hormonal drivers of melasma. Dr Ophelia can advise on hormonal treatments directly and facilitate referral to specialist colleagues in endocrinology, gynaecology, or menopause medicine where needed.
Yes. PicoSure PRO holds FDA approval specifically for melasma, a distinction no other laser holds. Melasma requires careful clinical assessment, precise laser settings, strict sun protection, and in most cases a combination of laser and prescription medical treatment.
Yes. PicoSure PRO's non thermal mechanism makes it among the most suitable laser options for skin of colour. At Dr Ophelia's clinic, parameters are carefully selected, progressively increased with caution, and results monitored objectively at every visit.
Dr Ophelia has formulated three prescription grade serums: a Hyperpigmentation Day Serum, a Hyperpigmentation Night Serum, and a Hyperpigmentation Eye Night Serum, specifically to complement and extend PicoSure PRO results. They are prescribed and dispensed through the clinic, not available over the counter.
Heliocare Fernblock is an oral photoprotection supplement with published evidence for reducing susceptibility to UV induced pigmentation from within. Dr Ophelia prescribes it alongside topical SPF 50 to reduce pigmentation recurrence, particularly in patients with melasma or post inflammatory hyperpigmentation at risk of UV triggered relapse.
Oral tranexamic acid is a prescription medication with an established evidence base for reducing melasma and certain types of hyperpigmentation by interrupting the signalling pathway that drives excess melanin production. It is prescribed and monitored appropriately for patients with moderate to severe melasma or persistent pigmentation.
Book Your PicoSure PRO Consultation in London
If you are concerned about melasma, pigmentation, dark circles, sun damage, post inflammatory hyperpigmentation, acne scarring, or uneven skin tone, book a consultation at Dr Ophelia's Harley Street clinic. Your skin will be assessed in full with VISIA skin analysis and medical photography, and a personalised 360 degree treatment plan created that addresses the cause of your pigmentation as well as its appearance.
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