
Profhilo Treatment London - Injectable Bio-Remodelling at Harley Street
Profhilo Treatment in London at Dr Ophelia's Harley Street clinic is a highly effective injectable skin bio-remodelling treatment that improves hydration, firmness, and elasticity across the face, neck, hands, and abdomen. As a Consultant Dermatologist, Dr Ophelia rarely uses it in isolation, combining it with prescription treatments, laser including Clear and Brilliant, PicoSure PRO and Fraxel, and other injectables such as anti wrinkle injections and polynucleotides, for skin rejuvenation beyond what a single injectable achieves.
Profhilo contains one of the highest concentrations of hyaluronic acid of any injectable available and works differently from a dermal filler: rather than adding volume, it spreads beneath the skin to hydrate and stimulate collagen and elastin, for skin that looks healthier, firmer, and more radiant, not treated.
What is Profhilo?
- One of the highest concentration hyaluronic acid injectables available
- Hydrates and bio-remodels, does not add volume or change facial shape
- Best results when combined with laser, injectables, and prescription skincare
- Suitable for face, neck, hands, and abdomen
Profhilo is an injectable bio-remodelling treatment made from ultra-pure, stabilised hyaluronic acid. It is not a filler and does not add structure or volume; injected just beneath the skin, it hydrates from within and stimulates collagen and elastin over the weeks that follow. With age the skin makes less hyaluronic acid, collagen, and elastin, causing dryness and crepey texture; Profhilo works in the dermal layers topical products cannot reach.
How Does Profhilo Work?
Profhilo delivers ultra-pure hyaluronic acid beneath the skin through a small number of precise injection points, and spreads through the tissue for a quick, visible improvement in skin quality. Over the following weeks the gradual release stimulates fibroblast activity, encouraging the skin to produce its own collagen and elastin, the bio-remodelling effect behind longer-term gains in firmness, elasticity, and texture.

Benefits of Profhilo Treatment
Profhilo is a foundational skin quality treatment, most powerful within a broader dermatologist-led plan.
Key benefits include:
- Deep hydration from within, at a level topical products cannot achieve
- Stimulation of collagen and elastin production through sustained hyaluronic acid release
- Improved skin firmness, elasticity, and bounce
- Smoother, healthier, more radiant looking skin
- Softening of fine surface lines and improvement in crepey texture
- Suitable for face, neck, hands, and abdomen
- No facial volume change or structural alteration
- Excellent combination treatment alongside anti wrinkle injections, polynucleotides, Clear and Brilliant, Fraxel, PicoSure PRO, and Thermage FLX
- Results further enhanced by prescription retinoids, growth factors, and antioxidant skincare available only through a Consultant Dermatologist
- Minimal downtime
- Two session standard protocol, with an optional third session for more dehydrated or photodamaged skin
Conditions Profhilo Can Treat
Profhilo may be suitable for a range of skin quality and ageing concerns, including:
- Skin laxity and mild sagging
- Crepey or dehydrated skin
- Dull, tired looking skin
- Fine lines and early wrinkles
- Loss of firmness and elasticity
- Neck ageing and skin crepiness
- Hand ageing and skin thinning
- Abdominal skin laxity, including post-pregnancy or post-weight-loss skin quality changes
- General improvement in skin quality and radiance as part of a preventative or maintenance plan
Your consultation establishes which areas would benefit and what combination of treatments to use alongside Profhilo.
What to Expect - Step by Step Treatment Process
Your treatment begins with a full skin assessment and consultation.
Dr Ophelia assesses hydration, firmness, elasticity, and texture across the face, neck, hands, and abdomen, with VISIA skin analysis for baseline data.
A tailored plan sets out whether Profhilo is used alone or with Clear and Brilliant or Fraxel laser, anti wrinkle injections, PicoSure PRO, Thermage FLX, polynucleotides, or prescription skincare.
A topical anaesthetic cream is applied for comfort, and injection points are deliberately few.
By Dr Ophelia Profhilo are injected just beneath the skin at chosen points, every injection performed personally by Dr Ophelia.
Aftercare guidance covers avoiding rubbing the treated areas, intense exercise, heat, and certain skincare products for a short period.
The standard protocol involves sessions four weeks apart to build a sustained collagen and elastin stimulating effect.
For more dehydrated, lax, or photodamaged skin, a third session four weeks later achieves the full bio-remodelling benefit.
Follow-up treatments every six to nine months maintain results, when Dr Ophelia also reviews prescription skincare, laser, or other treatments.

Results and Downtime
Immediately after treatment small superficial bumps may be visible at the injection points; these are expected and settle within 24 to 48 hours.
24 to 48 hours Any mild swelling, tenderness, or injection marks settle, and bruising tends to be minimal.
4 weeks results begin to appear, with skin feeling more hydrated and looking fresher, smoother, and more radiant; the second treatment is usually performed now.
8 weeks After the second treatment, firmness, texture, and glow improve further as stimulation builds.
6 to 12 months Results typically last around 6 to 12 months, depending on skin quality, age, and lifestyle, with supporting skincare and laser helping them keep improving; downtime is minimal and most patients return to normal activities immediately.

Pricing and Number of Sessions
The standard Profhilo protocol is two treatments, spaced four weeks apart. A third session is recommended for selected patients with more dehydrated or photodamaged skin. Maintenance treatments every six to nine months help sustain results.
Current pricing:
Face or neck: £500 per treatment Course of 3 treatments: £1,200
Pricing for other areas including hands and abdomen will be confirmed at consultation. Where Profhilo is combined with other treatments as part of a broader plan, Dr Ophelia's team will provide clear, personalised pricing for the full programme before treatment begins.
Why Dr Ophelia for Profhilo Treatment in London?
- A Consultant Dermatologist who combines Profhilo with prescription skincare, laser, and injectables for superior results
- Access to prescription retinoids, growth factors, and antioxidants only available through a dermatologist
- Clear and Brilliant and Fraxel laser available in clinic to complement and extend Profhilo's effects
- Every injection performed personally by Dr Ophelia, with the full clinical context of a dermatologist-led skin plan
Profhilo is one of the most effective injectable skin quality treatments available, but the result depends on the assessment, treatment plan, and skincare, managed differently by a Consultant Dermatologist than a standard aesthetic practitioner. Dr Ophelia can also prescribe pharmaceutical-grade retinoids, growth factor serums, and antioxidant formulations that maintain results between visits, for natural, dermatologist-led rejuvenation a single injectable cannot match.
HELP
Frequently Asked Questions - Profhilo Treatment London
Unlike cross-linked fillers that add volume, Profhilo spreads through the tissue to hydrate and stimulate collagen and elastin, improving skin quality rather than structure.
It improves hydration, firmness, and radiance and softens fine lines, working best with anti wrinkle injections, prescription skincare, and laser.
Yes. Neck skin is thinner and more prone to crepiness and laxity, and responds well to the deep hydration and bio-remodelling effect.
Yes. It improves the thinning, crepiness, and laxity common on the hands and abdomen, including after pregnancy or weight change.
For photoageing, texture, or pigmentation, she may add Clear and Brilliant, Fraxel laser, PicoSure Pro or Thermage FLX to target changes Profhilo does not.
As a Consultant Dermatologist she can prescribe pharmaceutical grade retinoids, growth factor formulations, antioxidant combinations, and bespoke compounded serums.
Two sessions four weeks apart, a third for more dehydrated or photodamaged skin, and maintenance every six to nine months.
Most notice improved hydration within the first few weeks, with firmness, texture, and glow developing after the second session.
Around 6 to 12 months, depending on skin quality, age, and lifestyle; prescription skincare and periodic laser help results continue.
It is generally well tolerated: a few injection points are used and topical numbing cream is applied beforehand.
Minimal. Small superficial bumps settle within 24 to 48 hours and mild bruising is usually brief.
Yes. Anti wrinkle injections soften expression lines, while Profhilo improves underlying skin quality, hydration, and firmness.
Book Your Profhilo Consultation in London
If you are concerned about skin laxity, dehydration, crepiness, fine lines, or loss of firmness in the face, neck, hands, or abdomen, book a Profhilo consultation at Dr Ophelia's Harley Street clinic, where your skin is assessed in full and a personalised plan created. For injectable skin rejuvenation within a comprehensive, Consultant Dermatologist-led framework rather than a single appointment, this is where to come.
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