



PREGNANCY SAFE ACNE SERUM
A daily serum for breakout-prone skin during pregnancy and breastfeeding, built without the ingredients most acne skincare quietly relies on.
£125 - 15ml refill pump, roughly a two-month supply
Subscription available, monthly refills, cancel any time.
Consultant Dermatologist · No Salicylic Acid · No Retinoids · Made Individually to Order · Fragrance-Free · Recyclable Refill Pump.
Recyclable Packaging
Suitable for Vegans and Filler Free
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Who This Is For
Anyone pregnant, trying to conceive, or breastfeeding, and dealing with breakout-prone or congested skin, which is extremely common in pregnancy given how much hormones drive both.
Anyone whose usual acne routine has been flagged by our skin questionnaire, or by their own reading, as containing salicylic acid or a retinoid, and who wants a straightforward like-for-like swap rather than rebuilding a routine from scratch.
The honest limit. This is a genuinely active formula, not a placebo swapped in because the real ingredients aren't allowed. But some of the most effective topical acne actives, the retinoid and antibiotic combination in the Night Serum, in particular, aren't appropriate here, so this treats breakout-prone skin somewhat more gently than the full two-part system does for most pregnancy-related breakouts; that's enough.
For severe or cystic acne during pregnancy, mention it to your midwife or obstetrician, and it's worth a skin consultation with me. Dr Ophelia sees pregnancy-related acne regularly, and while several of the stronger options the Night Serum, oral isotretinoin, AviClear wait until afterwards, some things are worth discussing sooner rather than waiting, including which oral options remain appropriate. Many of the oral antibiotics used for acne also aren't suitable in pregnancy, alongside the topical activities already excluded here, so this gap isn't unique to skincare. A skin consultation is £375 and is booked and charged separately from the serum.

What Goes In It
Function-based information about the ingredients in this formula. Not a claim to treat or cure acne, and not a substitute for mentioning any skincare product to your midwife or obstetrician.
- Niacinamide: A form of vitamin B3. It helps regulate oil production, calms the redness and inflammation under active breakouts, and supports the skin's own barrier, which matters more than usual in pregnancy, when skin is frequently more reactive than it was before. It's widely used and well tolerated, with no evidence of pregnancy-specific concerns.
- Zinc Sulphate: An essential mineral, well tolerated topically, and genuinely useful for congested and inflamed skin. Published evidence compares topical zinc treatment against oral antibiotics for acne with comparable results in some studies. Like niacinamide, it has no recognised pregnancy-specific concern at the concentrations used in a leave-on serum.
- What isn't in it, and why: Salicylic acid and any vitamin A derivative are left out entirely rather than included at a lower concentration, because there's no agreed safe threshold for pregnancy to formulate down to, and Dr Ophelia would rather remove the ingredient than guess at a number.
Fragrance, and the ingredients dermatologists most commonly see cause contact allergy, are left out of every formula in this range regardless of pregnancy, since they're among the commonest causes of skin irritation and pregnant skin tends to be more reactive, not less. If you already know you react to a particular ingredient, tell us in your questionnaire, and we'll exclude it from your formulation. This isn't a preservative-free product; a preservative system keeps a leave-on serum safe over the months you'll use a bottle, but because it's compounded fresh and used within months rather than sitting on a shelf for years, it doesn't need the heavier preservative load a long-life retail product carries.
The base is designed so you usually don't need a separate moisturiser, which matters in pregnancy when skin can be drier or more sensitive than usual. The pharmacy compounds every bottle individually to your formulation, based on Dr Ophelia's prescription for you, rather than as one of a small number of fixed batches manufactured in bulk, and it can be adjusted as things change over the course of your pregnancy.
How to Use
Apply one pump (around 0.5ml) to clean, dry skin daily. This is designed to be your whole regime for the duration, replacing both the usual Day and Night Serums rather than being added on top of anything containing the ingredients above.
A separate moisturiser usually isn't needed; the base is formulated to be hydrating enough on its own. Mention it to your midwife or obstetrician, as you should with any skincare or supplement during pregnancy; this is straightforward good practice, not a sign of concern about this specific formula. Expect the same adjustment window as any new product: a small amount of mild dryness in the first week or two is common as skin adjusts, and pregnancy skin can be more reactive than usual, so introduce it gradually if your skin tends to react.
Frequently Asked Questions
The honest answer is that it's a precaution rather than a proven danger at typical skincare concentrations, and the caution comes from salicylic acid's chemical relationship to aspirin and the wider advice around salicylates in pregnancy, particularly with regular or high-dose use. There's no need to panic about having used a salicylic acid cleanser before you knew it. Going forward, the straightforward thing to do is avoid it, which is what this serum is for.
Topical retinoids have far lower systemic absorption than oral retinoids known to cause harm, and the real-world risk from occasional use before you knew it is generally considered very low. Dermatology guidance still recommends avoiding all retinoids for the duration, out of caution rather than settled proof of topical harm, and this range follows that position. If you've used a retinol product without knowing you were pregnant, that's a conversation for your midwife or GP, not a reason to worry alone.
Beyond salicylic acid and retinoids, hydroquinone (used in some pigmentation products) and certain essential oils are also generally best avoided in pregnancy. If you're ever unsure about a product already in your routine, it's worth checking with your midwife, GP or a pharmacist rather than assuming it's fine.
It's a genuinely active formula. Niacinamide and zinc sulphate both have real evidence behind them for acne and congestion, and this isn't a compromise product assembled from whatever's left after removing the ingredients we can't use. It's a different, narrower toolkit than the full prescription system, chosen because it's the right toolkit for pregnancy.
Usually not. The base is designed to be hydrating enough on its own, which matters more in pregnancy when skin can be more sensitive.
Yes, this formula is for both pregnancy and breastfeeding, for the same reasons.
Once you're no longer pregnant or breastfeeding, and any specific timing your own doctor or midwife might want to flag has passed. The Night Serum in particular contains tretinoin, which needs to be fully clear of that consideration before restarting.
Acne Day Serum, Acne Night Serum
That's a reasonable and common time to switch, since it avoids having to change everything quickly once you get a positive test, particularly for tretinoin, which is best stopped ahead of trying to conceive rather than on the day you find out.
Fewer than outside pregnancy. Oral isotretinoin is never used in pregnancy, and many oral antibiotics used for acne aren't suitable either. This is a conversation for a skin consultation, not something to work out alone, since the safest option depends on exactly where you are in your pregnancy and your wider history.
No. This formula, like every serum in the range, is fragrance-free and formulated without the ingredients dermatologists most commonly see cause skin reactions. If you have a known sensitivity to a specific ingredient, mention it in your questionnaire, and we'll exclude it from your formulation.
Yes. The pharmacy compounds it individually to your formulation based on your prescription, not from a small number of fixed bulk batches, and it can be adjusted as things change over the course of your pregnancy.
Usually, since pregnancy-related breakouts are largely hormonal and tend to settle as hormones do postpartum, though that varies and breastfeeding has its own hormonal pattern, if breakouts persist well after you're back on your usual regime, it's worth a skin consultation.
Because pregnancy and breastfeeding both last a while, and a subscription is the simplest way to keep a working regime going without having to remember to reorder. You can pause, change, or cancel it whenever you like, which matters more here than with most products, since your needs may change from one trimester to the next.
15ml at one pump (about 0.5ml) daily is roughly a two-month supply.
Why do I have to answer questions before I can buy it?
Neither niacinamide nor zinc sulphate needs a prescription on its own. This bottle does, because it's compounded fresh to your prescription rather than being a fixed, mass-produced formula like the Day Serum. The short questionnaire, which also confirms you're pregnant or breastfeeding so the formula is right for you, comes before payment.
AWARD WINNING PRIVATE CONSULTANT DERMATOLOGIST
Dr. Ophelia Veraitch is a globally recognised dermatologist with an unparalleled educational foundation and international expertise in both medical and aesthetic dermatology.
As a private consultant on Harley Street, she specialises in diagnosing and treating complex skin and hair conditions while also offering a full range of professional aesthetic treatments.
Alongside her clinical work, Dr. Ophelia has developed her namesake line of prescription-strength skin and hair products, bringing her world-class knowledge and experience directly into patients’ hands, to continue treating their skin at home.
For After Pregnancy and Breastfeeding
Acne Day Serum.
The non-prescription-active morning serum to return to once retinoids and salicylic acid are no longer a consideration.
Know MoreAcne Night Serum.
The prescription-based evening formula, available after an assessment, for once you're ready for the fuller system.
Know MoreSkin Consultation, £375
For acne that's more than mild during pregnancy or afterwards, I deliver the route to oral isotretinoin, oral antibiotics, oral spironolactone, AviClear, or scarring treatment when the time is right, in the clinic, priced separately from the serums.
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